Wilms tumor (WT)1 gene expression in children with acute leukemia in Serbia
نویسندگان
چکیده
منابع مشابه
Over-expression of Wilm’s Tumor Gene 1 (WT1) in Iranian Patients with Acute Myeloblastic Leukemia
Background: The Wilm’s tumor gene 1 (WT1) encodes a zinc finger transcription factor that is inactivated in a subset of Wilm’s tumors. It plays a crucial role in growth, proliferation and development of some embryonic and adult organs. WT1 is expressed as a tumor associated antigen (TAA) in various types of solid and hematopoietic malignancies and can be employed as a useful marker for targeted...
متن کاملPrognostic implications of Wilms' tumor gene (WT1) expression in patients with de novo acute myeloid leukemia.
BACKGROUND AND OBJECTIVES The Wilms' tumor (WT1) gene is overexpressed in patients with most forms of acute leukemia. Several studies have reported the usefulness of quantitative assessment of WT1 expression as a molecular marker of minimal residual disease. However, the biological significance and the prognostic impact of WT1 overexpression in acute myeloid leukemia (AML) is still uncertain. ...
متن کاملAML1-ETO rapidly induces acute myeloblastic leukemia in cooperation with the Wilms tumor gene, WT1.
AML1-ETO, a chimeric gene frequently detected in acute myelogenous leukemia (AML), inhibits the differentiation of myeloid progenitors by suppressing genes associated with myeloid differentiation and increases the replating ability of clonogenic myeloid progenitors. However, AML1-ETO alone cannot induce AML and thus additional genetic events are required for the onset of AML. The Wilms tumor ge...
متن کاملover-expression of wilm’s tumor gene 1 (wt1) in iranian patients with acute myeloblastic leukemia
background: the wilm’s tumor gene 1 (wt1) encodes a zinc finger transcription factor that is inactivated in a subset of wilm’s tumors. it plays a crucial role in growth, proliferation and development of some embryonic and adult organs. wt1 is expressed as a tumor associated antigen (taa) in various types of solid and hematopoietic malignancies and can be employed as a useful marker for targeted...
متن کاملWilms' tumor gene (WT1) expression correlates with vascular epithelial growth factor (VEGF) in newly acute leukemia patients undergoing chemotherapy.
BACKGROUND Today, leukemia is one of the biggest problems worldwide. The Wilms' tumor gene (WT1) and the vascular endothelial growth factor (VEGF) gene are highly expressed in patients with various cancers. This study concerned the relationship between expression of WT1 and VEGF in patients with acute leukemia. MATERIALS AND METHODS We evaluated expression of WT1 mRNA and VEGF mRNA using real...
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ژورنال
عنوان ژورنال: ABI Genetika
سال: 2016
ISSN: 0534-0012,1820-6069
DOI: 10.2298/gensr1601409j